Abstract
Background Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that affects mostly females of childbearing age. The exact cause is still unknown, but hormonal and immunological features and genetic predisposition are considered likely etiological factors. Disease presentation is variable but is usually characterized by phases of remission and relapse. Objective This study was conducted to assess the knowledge and awareness of SLE among the general population of Makkah, Saudi Arabia. Methods Data were collected using an online survey created with Google Forms that was distributed to the residents of Makkah aged 18 years and older. The survey was disseminated between November 2022 and January 2023. Results A total of 488 participants were included in the study, and the mean age of the participants was 29.1 years; the majority were female (54%). Only 18.6% of the participants knew someone with SLE, while 52.3% had heard about SLE. Additionally, 79.9% of participants had below-average awareness of SLE. Moreover, 72.1% believed that awareness of SLE should be promoted; 65.5% knew about SLE from the Internet or e-resources. Finally, only 5.5% of the participants had heard about SLE from physicians. Conclusion This study showed an insufficient level of knowledge and awareness of SLE in the general population of Makkah. We recommend conducting physical and virtual disease awareness campaigns and activities to enhance the knowledge and awareness of SLE among the general population of Makkah and other parts of Saudi Arabia.