Abstract
Alzheimer's disease (AD) is associated with disruption at the level of a large-scale complex network. To explore the underlying mechanisms in the progression of AD, graph theory was used to quantitatively analyze the topological properties of structural and functional connections. Although an increasing number of studies have shown altered global and nodal network properties, little is known about the topologically convergent and divergent patterns between structural and functional networks among AD-spectrum patients. In this review, we summarized the topological patterns of the large-scale complex networks using multimodal neuroimaging graph theory analysis in AD spectrum patients. Convergent deficits in the connectivity characteristics were primarily in the default mode network (DMN) itself both in the structural and functional networks, while a divergent changes in the neighboring regions of the DMN were also observed between the patient groups. Together, the application of graph theory to large-scale complex brain networks provides quantitative insights into topological principles of brain network organization, which may lead to increasing attention in identifying the underlying neuroimaging pathological changes and predicting the progression of AD.