Abstract
Penile cancer is a rare cancer in developed nations, with metastatic disease seen in under 10% of cases at presentation. Treatment is multimodal and dependent on tumor stage, risk of recurrence, nodal involvement, and advancement of the disease. We report a case of a 49-year-old male with penile squamous cell carcinoma, who initially presented with a penile lesion but became lost to follow-up due to the coronavirus disease 2019 (COVID-19) pandemic. Therapies included surgical resection, chemotherapy, and external beam radiation therapy. His disease course was additionally complicated by its aggressive nature, poor response to first-line chemotherapy, and secondary nosocomial infections.