Sequential Chromogenic IHC: Spatial Analysis of Lymph Nodes Identifies Contact Interactions between Plasmacytoid Dendritic Cells and Plasmablasts
顺序显色 IHC：淋巴结空间分析确定浆细胞样树突状细胞与浆母细胞之间的接触相互作用
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作者：Natalie Claudio, My-Tien Nguyen, Adrian Wanner, Ferdinando Pucci
Significance
We present a comprehensive guide for developing customized biomarker panels to investigate cell-cell interactions in the context of immune responses in cancer. This approach revealed novel contact interactions between plasmablasts and plasmacytoid dendritic cells in lymph nodes from patients with head and neck cancer.
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