Reduced sensitivity of influenza A (H5N1) to oseltamivir
甲型流感病毒（H5N1）对奥司他韦的敏感性降低
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作者：Jennifer L McKimm-Breschkin, Paul W Selleck, Tri Bhakti Usman, Michael A Johnson
Abstract
We tested the neuraminidase drug sensitivity of clade 1 and clade 2 influenza A (H5N1). All viruses demonstrated similar sensitivity to zanamivir, but compared with the 2004 clade 1 viruses, the Cambodian 2005 viruses were 6-fold less sensitive and the Indonesian clade 2 viruses were up to 30-fold less sensitive to oseltamivir.
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