Abstract
OBJECTIVE: The objective of the study was to assess the prevalence of osteoporosis in patients with monoclonal gammopathy of undetermined significance (MGUS) and to determine the associated factors. MATERIALS AND METHODS: we conducted a case-control study, between January 2019 and April 2019, including patients with MGUS and age- and sex-matched healthy controls (one patient/three controls). For all participants, demographic and clinical data were collected as results of bone mineral density by two-photon X-ray absorptiometry at the lumbar spine and femoral neck. RESULTS: In our series, we included 120 participants: 30 patients with MGUS and 90 healthy controls. In the MGUS carrier group, the mean age was 66.26 ± 8.61 years. The mean monoclonal peak was 11.57 g/L. Densitometric osteoporosis was noted in 12 (40%) patients with MGUS versus 17 (18.9%) in the control group ( P = 0.021). In addition, only one patient with MGUS had a vertebral fracture. On multivariate analysis, associated factors with osteoporosis in the MGUS group were age (odds ratio [OR] = 1.14; confidence interval [CI] [1.03-1.26]; P < 0.05) and previous fracture (OR = 3.03; CI [1.22-15.06]; P < 0.05). CONCLUSION: Our study suggests an increased risk of osteoporosis in patients with MGUS.