Highly efficient electrocatalytic oxidation of levodopa as a Parkinson therapeutic drug based on modified screen-printed electrode

基于改性丝网印刷电极的左旋多巴高效电催化氧化法及其在帕金森病治疗中的应用

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Abstract

The current study presents the creation of a straightforward and sensitive sensor based on ZnO/Co(3)O(4) nanocomposite modified screen-printed electrode (ZnO/Co(3)O(4)NC/SPE) for levodopa determination. At ZnO/Co(3)O(4)NC/SPE, an oxidative peak for levodopa solution in pH 6.0 phosphate buffer solution (PBS) were seen that were both more resolved and more enhanced. Levodopa was measured using differential pulse voltammetry (DPV), which showed an excellent linear range (0.001-800.0 μM) and detection limit (0.81 nM). The presence of interference did not affect the electrochemical response of levodopa at ZnO/Co(3)O(4)NC/SPE, demonstrating high selectivity. Levodopa in a real samples have been successfully detected using the manufactured sensor.

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