Abstract
This case report examines the difficulties faced by a couple with 11 years of primary infertility. Based on the diagnostic evaluation, it was determined that the male was a necrozoospermia patient, while the female had unilateral cornual blockage and polycystic ovarian syndrome (PCOS) with diabetes mellitus (DM) symptoms identified. A comprehensive approach was used in the treatment for the female patient, which included a gonadotropin-releasing hormone (GnRH) short antagonist protocol, a GnRH agonist (GnRHa) trigger, assisted hatching (AH), and the use of the hypo-osmotic swelling test (HOST) to gauge the viability of the sperm. The successful outcome, as evidenced by the increasing levels of beta-human chorionic gonadotropin (β-hCG) and a successful embryo transfer, highlights the effectiveness of a customized and multifaceted approach in managing intricate infertility problems. This instance offers insightful information about the way modern reproductive technologies can be successfully integrated with specialized treatment plans to achieve successful outcomes in difficult cases of infertility.