Abstract
An efficient synthesis of the C14-C21 acid fragment of cytochalasin Z(8) was accomplished in 10 steps with 14% overall yield. Boron-mediated anti-selective aldol condensation and Pd(OAc)(2)-Aphos-Y-catalysed B-alkyl Suzuki-Miyaura cross-coupling were employed to construct the requisite C17 and C18 stereogenic centres and alkene subunit.