Abstract
The space surrounding the body, and the regulation of this buffer zone play a central role in adaptive behavior, with direct implications for psychopathology. The physical distance that we choose to maintain between ourselves and others for social comfort is known as Interpersonal Distance (IPD), whereas the action space that marks the perceptual border between the self and the external world is known as Peripersonal Space (PPS ). While both IPD and PPS represent personal space, they are distinct constructs, each associated with different methodologies. Here we review the existing literature on IPD and PPS to elucidate their distinct and common contributions to psychiatric conditions including schizophrenia, autism, anxiety, and others. Altered representation and regulation of IPD and PPS were associated with clinical symptoms and social impairments across a wide range of psychiatric disorders, underscoring the important role of the self-other boundary and personal space regulation in adaptive social behavior. Future research should clarify the relationship between IPD and PPS and specify risk factors for self-other boundary dysregulation and associated psychopathologies.