Cyaphide-Azide 1,3-Dipolar Cycloaddition Reactions: Scope and Applicability

氰化物-叠氮化物1,3-偶极环加成反应:范围和适用性

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Abstract

Several examples of the cyaphide-azide 1,3-dipolar cycloaddition reaction to afford metallo-triazaphospholes are reported. The gold(I) triazaphospholes Au(IDipp)(CPN(3) R) (IDipp=1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene; R=(t) Bu, Ad, Dipp), magnesium(II) triazaphospholes, {Mg((Dipp) NacNac)(CPN(3) R)}(2) ((Dipp) NacNac=CH{C(CH(3) )N(Dipp)}(2) , Dipp=2,6-diisopropylphenyl; R=(t) Bu, Bn), and germanium(II) triazaphosphole Ge((Dipp) NacNac)-(CPN(3) (t) Bu) can be prepared straightforwardly, under mild conditions and in good yields, in a manner reminiscent of the classic alkyne-azide click reaction (albeit without a catalyst). This reactivity can be extended to compounds with two azide functional groups such as 1,3-diazidobenzene. It is shown that the resulting metallo-triazaphospholes can be used as precursors to carbon-functionalized species, including protio- and iodo-triazaphospholes.

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