α-Alkylation of Mono-Carbonyl Compounds with N-Allylamines through Cooperative Actions of Lewis Acids and a Brønsted Base

路易斯酸和布朗斯台德碱的协同作用下,N-烯丙胺与单羰基化合物的α-烷基化反应

阅读:2

Abstract

We present a strategy for the union of N-allylamines and carbonyl compounds by the concerted action of B(C(6)F(5))(3) and a N-based Brønsted base under redox-neutral conditions. The reaction of in situ generated conjugated iminium ions and enolates affords δ-aminocarbonyl compounds without waste generation. Furthermore, we describe that the cooperative action of B(C(6)F(5))(3), a chiral Zn-based complex, and an amine facilitates the stereoselective reaction of a glycinate Schiff base ester and an N-allylamine to afford an α-substituted α-amino ester.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用;引用内容仅为补充信息,不代表本站立场。

2、若认为本页面引用内容涉及侵权,请及时与本站联系,我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容,需注明“来源:[生知库]”并获得授权;使用引用内容的,需自行联系原作者获得许可。

4、投稿及合作请联系:info@biocloudy.com。