Reversal of Retinal Vascular Leakage and Arrest of Progressive Retinal Nonperfusion With Monthly Anti-Vascular Endothelial Growth Factor Therapy for Proliferative Diabetic Retinopathy

We report a case of proliferative diabetic retinopathy (PDR) with severe, vision-threatening retinal non-perfusion (RNP) in which anti-vascular endothelial growth factor (VEGF) therapy resulted not only PDR reversal but also in arrest of RNP and resolution of retinal vascular leakage which had previously preceded vascular dropout and progressive RNP in the same patient.