NF-κB and STAT3 co-operation enhances high glucose induced aggressiveness of cholangiocarcinoma cells

The present report aimed to investigate the underlying genes and pathways of high glucose driving cholangiocarcinoma (CCA) aggressiveness. Main

We screened and compared the gene expression profiles obtained by RNA sequencing, of CCA cells cultured in high and normal glucose.

These results indicate that NF-κB is activated by high glucose and they suggest that NF-κB interaction with STAT3 enhances CCA aggressiveness. Therefore, targeting multiple pathways such as STAT3 and NF-κB might improve CCA treatment outcome especially in condition such as hyperglycemia.