Abstract
The association between cereal intake and inflammatory joint disease remains controversial. This study aims to use Mendelian randomization to comprehensively evaluate the causal relationship between cereal grain intake and Inflammatory joint diseases, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. This investigation used publicly available data from genome-wide association studies to aggregate statistics on the association between cereal intake and inflammatory joint disease. Several methods were employed to estimate 2-sample causality. The results of the random-effects inverse variance-weighted method analysis indicated that higher cereal intake reduced the risk of developing rheumatoid arthritis (odds ratio [OR] = 0.554; 95% confidence interval [CI]: 0.324-0. 948; P = .031) and psoriatic arthritis (OR = 0.336; 95% CI: 0.123-0.918; P = .033), and the results of the Mendelian randomization-Egger regression analysis showed no horizontal pleiotropy (P > .05) for the included single nucleotide polymorphisms. Using the leave-one-out method, no single nucleotide polymorphism was found to affect the overall effect estimate significantly, and there was no heterogeneity. Cereal intake had no causal effect on the risk of developing ankylosing spondylitis (OR = 0.636; 95% CI: 0.236-1.711; P = .370). There is genetic evidence that cereal consumption reduces the risk of developing Inflammatory joint diseases such as rheumatoid arthritis and psoriatic arthritis.