Knockdown of the GABARAP ortholog Atg8a elicits deficits in learning and promotes obsessive behaviors in Drosophila melanogaster

In humans, trafficking of the GABA(A) receptor by GABARAP can lead to obsessive behaviors and learning deficits often in seen in neurological disorders such as Tourette's Syndrome. We find that in Drosophila melanogaster , Atg8a , the ortholog of the human GABARAP gene, is necessary in the nervous system for learning and suppression of excessive grooming. These results suggest that knocking down Atg8a in neurons of Drosophila produces a phenotype similar to that seen in human patients, potentially allowing for use of an Atg8a knockdown background as a suitable invertebrate model for related neurological conditions.