Resveratrol natural product inspired compound as a potent neuroprotectant against acute oxidative stress

白藜芦醇是一种天然产物,其衍生的化合物可作为一种有效的神经保护剂,对抗急性氧化应激。

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Abstract

Resveratrol as well as natural products biosynthetically derived from it, have been shown to have protective effects against oxidative stress. However, these compounds possess poor druglike properties. At sub-nanomolar concentrations, a novel compound (RVM-6) inspired by a resveratrol natural product prolongs synaptic viability in neuromuscular junctions in D. melanogaster exposed to acute oxidative stress.

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