Abstract
OBJECTIVE: To report a successful case of oocyte cryopreservation and subsequent in vitro fertilization (IVF) in a transgender male receiving continued testosterone gender-affirming hormone therapy, followed by reciprocal embryo transfer (ET). DESIGN: A case report of a rare case of fertility preservation in a transgender man with concomitant use of testosterone therapy for 4 years before and during ovarian stimulation. SETTING: Private fertility clinic with university affiliation. PATIENTS: A 26-year-old transgender man undergoing oocyte cryopreservation before gender-affirming surgery. INTERVENTIONS: Fertility preservation using oocyte cryopreservation and IVF with reciprocal fresh ET into a cisfemale partner. MAIN OUTCOME MEASURES: Successful oocyte cryopreservation, oocyte thawing, and reciprocal IVF cycle. RESULTS: Oocyte cryopreservation of 29 mature oocytes. Sixteen mature oocytes survived the thaw, and 12 were fertilized with intracytoplasmic sperm injection. A fresh ET of an advanced blastocyst resulted in a clinical pregnancy and live birth. CONCLUSIONS: Fertility preservation with oocyte cryopreservation or IVF with embryo cryopreservation is feasible for patients on continued long-term testosterone gender-affirming therapy. Future studies on egg quality and reproductive outcomes are required. Our case report demonstrates a promising outcome in this patient population.