Abstract
OBJECTIVES: The current study aims to explore the relationship between the frequency of volunteering and biological aging, as measured by epigenetic age acceleration. It also investigates whether this relationship differs between retired and working older adults. Understanding this connection could inform interventions promoting healthy aging and reducing age-related chronic health conditions. METHOD: Data were derived from the Health and Retirement Study (HRS), including pre-treatment covariates (2012), volunteer frequency and work status (2014), and five DNA methylation measures (2016) (N = 2,605). Generalized linear models were estimated to examine the relationship between volunteering and epigenetic age acceleration, stratified by retirement status. The analyses adjusted for relevant covariates and utilized energy balancing weights to account for selection into volunteering. RESULTS: Findings show that volunteering, especially for 1-49 h per year and 200+ hours per year, was linked to less epigenetic age acceleration, with significant effects on DNA methylation measures PhenoAge, GrimAge, and DunedinPACE clocks. Among retired individuals, moderate volunteering was significantly associated with decelerated epigenetic age acceleration, indicating greater benefits for retirees compared to working individuals. CONCLUSIONS: The study found that frequent volunteering may lead to decelerated epigenetic aging, potentially offering a public health intervention to enhance health and quality of life among older adults. Further research is needed to confirm these findings and to understand how volunteering might differentially impact retired and working individuals. Such insights could guide the development of targeted strategies to promote healthy aging and address age-related health disparities.