Abstract
Irregularly shaped wounds cause severe chronic infections, which have attracted worldwide attention due to their high prevalence and poor treatment outcomes. In this study, we designed a new composite functional dressing consisting of traditional Chinese herb carbonized plant powder (CPP) and a polyacrylic acid (PAA)/polyethylenimine (PEI) gel. The rapid gelation of the dressing within 6-8 s allowed the gel to be firmly attached to an irregularly shaped wound surface and avoided powder detachment. In addition, through an infrared thermography analysis, a coagulation assay, and a morphological examination of regenerative tissue in animal wound models, it was found that the dressing substrates had synergistic effects on photothermal sterilization, rapid hemostasis, and anti-inflammatory activity, thereby achieving an 88% wound closure rate on the 9th day after the formation of the wound. This multifunctional hemostatic material is expected to be adaptable to irregular wounds and promote rapid wound healing.