Abstract
Acute appendicitis is a common reason for admission to the Emergency Department (ED). It affects almost 70% of people under 30 years of age and 10% over 60 years of age. Its diagnosis includes the combination of clinical signs, laboratory tests and imaging. For years, surgical appendectomy has been the first-line therapy for acute appendicitis, but currently the management has shown some changes, in particular in patients with uncomplicated appendicitis. Recent studies have investigated the use of probiotics as an adjunctive therapy with promising results in conferring health benefits to patients with acute appendicitis. The aim of our review is to summarize the results of clinical studies about probiotics and the immunological response in acute appendicitis, discussing the limitations and future directions of this research.