Abstract
This case report examines a rare occurrence of chronic spontaneous urticaria (CSU) following the administration of the CoronaVac vaccine for COVID-19. The patient developed persistent urticarial lesions that appeared and disappeared over an extended period after receiving the vaccine. The diagnosis of CSU was supported by histopathological examination and the close temporal correlation between symptom onset and vaccination. The discussion focuses on the immune mechanisms involved in CSU, the potential triggers of allergic reactions to COVID-19 vaccines, and the importance of further research to identify specific allergenic components. This case underscores the need for vigilance in monitoring and reporting adverse events related to COVID-19 vaccination to ensure vaccine safety and optimize public health strategies.