Abstract
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is an autoimmune disease that involves GFAP autoantibodies in the cerebrospinal fluid (CSF) and serum. Clinical manifestations exhibit diverse symptoms affecting various brain regions and spinal cord. Diagnosis challenges persist due to the absence of standardized criteria, yet steroid therapy shows promise despite varied responses. Herein we present the case of a 30-year-old male with meningoencephalomyelitis symptoms, later diagnosed with autoimmune astrocytopathy. Treatment involved plasmapheresis, corticosteroids, and mycophenolate mofetil, with a positive outcome. Neurourological complications, including acute urinary retention, prompted catheterization, and urodynamic studies revealed detrusor overactivity. Timely intervention enabled the restoration of bladder function, underscoring the importance of specialized care in complex neurologic conditions for improving patients' quality of life (QoL). This case emphasizes the significance of early neurourological intervention and the role of specialized centers in delivering tailored care for better patient outcomes.