Abstract
We present the case of a 54-year-old man with a cystic formation measuring 0.6 cm in the head of the epididymis. Histologically, the lesion showed intense granular eosinophilic transformation of the cytoplasm. The finding was assessed as eosinophilic metaplasia (EM) and showed association with and deposition of lipofuscin pigment. The EM in the epididymis presents a sign of intracytoplasmic lysosomal accumulation, which serves as a microscopic indicator of ductal obstruction. The presented unique finding was compared with the data reported in the literature. In this case report, we describe an extremely rare metaplastic lesion in the epididymis.