Conclusion
The expression level of serum PTTG1 may be closely related to the clinicopathological characteristics and prognosis of patients with laryngeal cancer, and its high expression may be one of the indicators of poor prognosis of patients with laryngeal cancer. 目的：探讨喉癌患者血清垂体肿瘤转化基因（PTTG1）表达水平与临床病理特征及预后的相关性。 方法：采用酶联免疫吸附法检测80例喉癌患者及60例声带息肉患者血清PTTG1的表达水平，分析喉癌患者临床病理特征与血清PTTG1表达水平的关系，Cox回归分析影响喉癌预后的相关因素。 结果：血清PTTG1表达水平在喉癌患者明显高于声带息肉患者，差异有统计学意义（P<0.05）。淋巴结转移、肿瘤TNM分期越高及分化程度越低，患者血清PTTG1表达水平越高（P<0.05）。预后生存分析中，单因素分析结果显示淋巴结转移、肿瘤TNM分期、分化程度、肿瘤直径及PTTG1表达与喉癌预后有关（P<0.01）；Cox多因素回归分析结果显示淋巴结转移（HR=2.651，95%CI1.452～4.823，P=0.002）、肿瘤TNM分期高（HR=2.944，95%CI1.155～6.189，P=0.026）、分化程度低（HR=1.620，95%CI1.133～2.169，P=0.003）及PTTG1高表达（HR=3.511，95%CI1.432～7.156，P<0.001）均是影响喉癌患者预后的危险因素。 结论：血清PTTG1的表达水平可能与喉癌患者的临床病理特征及预后密切相关，其高表达可能是喉癌患者预后不良的指标之一。.
Objective
To investigate the correlation between the expression level of serum pituitary tumor transforming gene（PTTG1） and clinicopathological characteristics and prognosis in patients with laryngeal cancer. Method:Enzyme-linked immunosorbent assay was used to detect the expression of serum PTTG1 in 80 patients with laryngeal cancer and 60 patients with vocal cord polyps. The relationship between the clinicopathological characteristics of patients with laryngeal cancer and the expression of serum PTTG1 was analyzed. Cox regression analysis was used to analyze related factors affecting the prognosis of laryngeal cancer. Result:Serum PTTG1 expression level in patients with laryngeal cancer was significantly higher than that in patients with vocal cord polyps, and the difference was statistically significant（P<0.05）. The higher the lymph node metastasis, the higher the tumor TNM stage, and the lower the degree of differentiation, the higher the serum PTTG1 expression level（P<0.05）. In the prognostic survival analysis, univariate analysis showed that lymph node metastasis, tumor TNM stage, degree of differentiation, tumor diameter, and expression of PTTG1 were related to the prognosis of laryngeal cancer（P<0.01）. Cox regression multivariate showed lymph node metastasis（HR=2.651, 95%CI1.452-4.823, P=0.002）, high tumor TNM stage（HR=2.944, 95%CI1.155-6.189, P=0.026）, and low differentiation（HR=1.620, 95%CI1.133-2.169, P=0.003） and high PTTG1 expression（HR=3.511, 95%CI1.432-7.156, P<0.001） were risk factors affecting the prognosis of patients with laryngeal cancer.