Abstract
This study aims to observe the clinical efficacy and safety of rigid gas permeable corneal contact lenses (RGP-CLs) wearing after femtosecond laser-assisted minimally invasive lamellar keratoplasty (FL-MILK) in progressive and advanced keratoconus eyes. Twenty-five patients (27 eyes) fitted with RGP-CLs after FL-MILK were enrolled, and 22 grading-matched keratoconus patients (23 eyes) as a control group. Corneal morphological data, diopter, best corrected vision, corneal endothelium, non-invasive tear film rupture time (NIBUT), corneal perception and comfort questionnaire were analysed before and after wearing RGP-CLs. In the FL-MILK group, the flat K, steep K and Kmax of the corneal anterior surface were decreased by 3.05D, 3.48D and 7.17D respectively after surgery (P = 0.011, 0.004 and 0.007). The central corneal thickness increased by 175.29 μm (P < 0.001). The basic curve of RGP-CLs after surgery was about 0.23 mm flatter than that before surgery (P = 0.013). There was no statistical difference in the best corrected vision and the comfort of wearing RGP-CLs before and after FL-MILK (P = 0.923, 0.391). Compared with the control group, there was no significant difference in vision improvement by RGP-CLs (P = 0.669). During the follow-up, the comfort of wearing RGP-CLs in the two groups was good, and no obvious adverse events were observed. This study showed MILK significantly increases corneal thickness and flattens corneal curvature, achieving good RGP-CLs corrected vision.