Training Status as a Marker of the Relationship between Nitric Oxide, Oxidative Stress, and Blood Pressure in Older Adult Women

训练状态作为老年女性一氧化氮、氧化应激和血压之间关系的标志

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作者:André Mourão Jacomini, Hugo Celso Dutra de Souza, Danielle da Silva Dias, Janaina de Oliveira Brito, Lucas Cezar Pinheiro, Anderson Bernardino da Silva, Roberta Fernanda da Silva, Atila Alexandre Trapé, Kátia De Angelis, José Eduardo Tanus-Santos, Sandra Lia do Amaral, Anderson Saranz Zago

Abstract

The purpose of this study was to evaluate the influence of functional fitness and oxidative capacity on the nitric oxide concentration associated with hemodynamic control in older adult women. The sample consisted of 134 women (65.73 ± 6.14 years old). All subjects underwent a physical examination to assess body mass index, waist-hip ratio, body fat measurement by dual energy X-ray absorptiometry, and blood pressure (BP). Training status (TS) was evaluated by indirect determination of maximal oxygen uptake by a treadmill test using Balke protocol modified for older adults. Functional fitness was also evaluated through a "Functional Fitness Battery Test" to determine the general fitness functional index (GFFI). All participants were separated according to the functional fitness (TS1, very weak and weak; TS2, regular; TS3, good and very good). Plasma blood samples were used to evaluate prooxidant and antioxidant activity and nitrite and nitrate concentrations. The general results of this study showed that good levels of TS were related to lower levels of lipoperoxidation and protein damage, higher levels of antioxidant, and higher concentration of nitrite and nitrate. This combination may be responsible for the lower levels of BP in subjects with better TS.

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