Abstract
BACKGROUND AND PURPOSE: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) describes tissue microvasculature and has prognostic and predictive potential in radiotherapy for head and neck cancer (HNC). However, lack in standardization of DCE-MRI hinders comparison of studies and clinical implementation. This study investigated the accuracy and robustness of the population arterial input function (AIF), correlations between pharmacokinetic parameters and their association to T stage and human papillomavirus (HPV) status for HNC. MATERIALS AND METHODS: DCE-MRI was acquired for 44 HNC patients. Population AIFs were calculated with six different approaches. DCE-MRI was analysed in primary and lymph node tumours using Tofts model (TM) with population AIFs and individual AIFs, extended TM (ETM) with individual AIFs, Brix model (BM), and areas under the curve (AUCs). Intraclass correlation, concordance correlation, Pearson correlation and Whitney Mann U test helped examining the robustness and accuracy of population AIF, correlations between DCE-MRI parameters and their association to T stage and HPV status, respectively. RESULTS: The population AIF was robust but differed from individual AIFs. There was significant correlation between K(trans)(TM/ETM) and v(e, TM/ETM), and K(trans)(TM/ETM) and K(ep, TM/ETM). A(Brix) and AUCs correlated for lymph nodes. K(ep, Brix) correlated with A(Brix), K(trans)(TM/ETM) and K(ep, TM/ETM) for primary tumours. K(ep, TM) significantly decreased with increasing T stage. Both the correlations and the parameters' association to T stage were stronger for HPV negative lesions. CONCLUSIONS: Individual AIF was preferred for accurate pharmacokinetic modelling of DCE-MRI. DCE-MRI parameters and their correlations were affected by the lesion type, HPV status and T staging.