Abstract
Multi-criteria optimization (MCO) function has been available on commercial radiotherapy (RT) treatment planning systems to improve plan quality; however, no study has compared Eclipse and RayStation MCO functions for prostate RT planning. The purpose of this study was to compare prostate RT MCO plan qualities in terms of discrepancies between Pareto optimal and final deliverable plans, and dosimetric impact of final deliverable plans. In total, 25 computed tomography datasets of prostate cancer patients were used for Eclipse (version 16.1) and RayStation (version 12A) MCO-based plannings with doses received by 98% of planning target volume having 76 Gy prescription (PTV(76)D(98%)) and 50% of rectum (rectum D(50%)) selected as trade-off criteria. Pareto optimal and final deliverable plan discrepancies were determined based on PTV(76)D(98%) and rectum D(50%) percentage differences. Their final deliverable plans were compared in terms of doses received by PTV(76) and other structures including rectum, and PTV(76) homogeneity index (HI) and conformity index (CI), using a t-test. Both systems showed discrepancies between Pareto optimal and final deliverable plans (Eclipse: -0.89% (PTV(76)D(98%)) and -2.49% (Rectum D(50%)); RayStation: 3.56% (PTV(76)D(98%)) and -1.96% (Rectum D(50%))). Statistically significantly different average values of PTV(76)D(98%,)HI and CI, and mean dose received by rectum (Eclipse: 76.07 Gy, 0.06, 1.05 and 39.36 Gy; RayStation: 70.43 Gy, 0.11, 0.87 and 51.65 Gy) are noted, respectively (p < 0.001). Eclipse MCO-based prostate RT plan quality appears better than that of RayStation.