Conclusion
MgSO4 may be a promising hypothermia infusion solution to facilitate the recovery of neurological function in AIS patients.
Methods
First, IA-SCMI was performed in rats subjected to the middle cerebral artery occlusion. The effect of combined hypothermia and MgSO4 treatment on different neurovascular (NVU) cells after oxygen-glucose deprivation/reoxygenation (OGD/R) injury was examined.
Results
Compared with the IA-SCSI or IA-MgSO4 infusion alone, IA-SCMI offered the best protective effect by improving neurological defects, and alleviating brain integrity damage and CBF reduction. Meanwhile, in vitro results revealed that the combination of hypothermia and MgSO4 provided maximum protection to the NVU cells, and this protective effect was mainly achieved through the regulation of Ca2+ homeostasis in different cells.