Abstract
Leiomyomas are benign smooth muscle tumors predominantly found in the uterine wall, with rare occurrences in the gastrointestinal tract. Here, we report a rare case of a leiomyoma that was incidentally found in the rectum of an asymptomatic male who underwent a routine screening colonoscopy. Histopathological examination confirmed the diagnosis of leiomyoma. This case emphasizes the significance of routine colonoscopic screenings in the early detection of asymptomatic colorectal lesions and the pivotal role of Immunohistochemistry in differentiating rectal leiomyomas from other mesenchymal neoplasms, guiding appropriate management strategies.