Abstract
Amyloidosis is often known as "the great imitator," as the clinical diagnosis of AL amyloidosis is quite challenging and often delayed, given multi-organ involvement. We present a unique case of an elderly male who presented with an eight-month history of progressive lower extremity edema and dyspnea and was admitted for syncope, anasarca, and severe dyspnea. He was diagnosed with renal failure, nephrotic syndrome, a large renal mass, and severe non-ischemic cardiomyopathy. A renal resection was performed, and renal cell carcinoma (RCC) and light chain (AL) amyloidosis were diagnosed.