ATP and control of intracellular growth of mycobacteria by T cells

ATP 和 T 细胞对分枝杆菌细胞内生长的控制

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作者:David H Canaday, Reza Beigi, Richard F Silver, Clifford V Harding, W Henry Boom, George R Dubyak

Abstract

Extracellular ATP at millimolar concentrations inhibits growth of mycobacteria in human macrophages. Whether T cells can produce sufficient ATP is unknown. CD4(+) and CD8(+) T cells did not release sufficient ATP through either degranulation or lysis of bystander cells to restrict growth of Mycobacterium bovis BCG in monocytes.

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