Abstract
A novel diacetylpyridylcarbohydrazide-DAPyCOHz-based manganese(II) chelate with dipicolylamine/zinc(II) (DPA/Zn(2+)) arms (MnLDPA-Zn2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) T(1) contrast applications. Compound 2 shows enhanced relaxivity (r(1) = 11.52 mM(-1) s(-1)) upon selective ATP binding over other phosphates.