Abstract
BACKGROUND: Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines recommend the diagnosis of chronic obstructive pulmonary disease (COPD) only in patients with a post-bronchodilator forced expiratory volume in 1 second to forced vital capacity ratio (FEV(1)/FVC) less than 0.7. However the impact of this recommendation on clinical practice is unknown. RESEARCH QUESTION: What is the effect of a documented post-bronchodilator FEV(1)/FVC < 0.7 on the diagnosis and treatment of COPD? STUDY DESIGN AND METHODS: We used a national electronic health record database to identify clinical encounters between 2007 to 2022 with patients 18 years of age and older in which a post-bronchodilator FEV(1)/FVC value was documented. An encounter was associated with a COPD diagnosis if a diagnostic code for COPD was assigned, and was associated with COPD treatment if a prescription for a medication commonly used to treat COPD was filled within 90 days. We used a regression discontinuity design to measure the effect of a post-bronchodilator FEV(1)/FVC < 0.7 on COPD diagnosis and treatment. RESULTS: Among 27 817 clinical encounters, involving 18 991 patients, a post-bronchodilator FEV(1)/FVC < 0.7 was present in 14 876 (53.4%). The presence of a documented post-bronchodilator FEV(1)/FVC < 0.7 had a small effect on the probability of a COPD diagnosis, increasing by 6.0% (95% confidence interval [CI] 1.1% to 10.9%) from 38.0% just above the 0.7 cutoff to 44.0% just below this cutoff. The presence of a documented post-bronchodilator FEV(1)/FVC had no effect on the probability of COPD treatment (-2.1%, 95% CI -7.2% to 3.0%). INTERPRETATION: The presence of a documented post-bronchodilator FEV(1)/FVC < 0.7 has only a small effect on the probability that a clinician will make a guideline-concordant diagnosis of COPD and has no effect on corresponding treatment decisions.