Mild Behavioral Impairment association with the Visual Cognitive Assessment Test (VCAT) in a Southeast Asian Population with Vascular Mild Cognitive Impairment ‐ Biomarkers and Cognition Study, Singapore BIOCIS

新加坡生物标志物与认知研究:血管性轻度认知障碍患者中,视觉认知评估测试(VCAT)与轻度行为障碍的关联——新加坡生物信息学与认知研究所(BIOCIS)

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Abstract

BACKGROUND: The Visual Cognitive Assessment Test (VCAT) is a visual based, language neutral cognitive assessment validated across cultures and ethnicities, that allows for early diagnosis of cognitive impairment. The VCAT assess domains of cognition – Memory, Visuospatial function, attention, language and Executive function. The Mild Behavioural Impairment Checklist (MBI‐C) was developed to assess five domains of NPS – Decreased motivation, emotional dysregulation, impulse control, social inappropriateness and abnormal beliefs/perceptions Current research indicates an association between MBI symptom severity and poorer cognitive performance in the domains of memory. We examined the association between mild behavioural impairment and domains of cognition as assessed by the VCAT in a multi‐ethnic Southeast Asian population. METHOD: 204 participants with vascular mild cognitive impairment (VMCI) were recruited from the community living in Singapore. VMIC was defined by Fazekas White Matter Hyperintensity(WMH) visual ratings of 4 and above. The mean age = 66.82 years, mean education = 13.54years with 39.8% males. Participants underwent neuropsychological assessments including the VCAT administered by trained raters and self‐reported questionnaires including the Mild Behavioural Impairment‐Checklist (MBI‐C). RESULT: The VCAT‐Attention domain had a significant negative correlation with MBIC‐social subdomain (r = ‐0.276, p<0.05). With every 1 point increase in VCAT‐Attention. MBIC‐social subdomain decreased by 9% (estimate ‐0.357; 95% CI[0.516, 0.239]; p = 0.022). CONCLUSION: Current research indicated that social isolation is one of the biggest risk factors for cognitive impairment, and our results reveal that social issues are associated with behavioural impairment as well. Attentional difficulties could lead to issues in inhibitory control, resulting in social inappropriateness. The V‐CAT’s ability to associate specific subdomains with MBI‐C subdomains suggest both tools could be a valuable tool for early detection and intervention in cognitive disorders.

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