Glycine-Induced Hypo-Osmolar Hyponatremia and Hyperammonemia: A Case Report of Operative Hysteroscopy Intravascular Absorption (OHIA) Syndrome

甘氨酸诱发的低渗性低钠血症和高氨血症:一例手术宫腔镜血管内吸收(OHIA)综合征病例报告

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Abstract

We discuss a case of a 35-year-old female with no known medical conditions, who developed symptoms of confusion, disorientation, and seizures after an uncomplicated hysteroscopic myomectomy of her uterine fibroid using 1.5% glycine solution under general anesthesia (GA). Thanks to prompt diagnosis, management, and periodic follow-up of the patient, her symptoms resolved within 72 hours after the involvement of a multidisciplinary team. Hypo-osmolar hyponatremia with hyperammonemia is a serious and fatal metabolic disturbance seen in patients with glycine intoxication and it requires urgent treatment.

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