Abstract
Mitochondria are responsible for ATP production but are also known as regulators of cell death, and mitochondrial matrix Ca(2+) is a key modulator of both ATP production and cell death. Although mitochondrial Ca(2+) uptake and efflux have been studied for over 50 years, it is only in the past decade that the proteins responsible for mitochondrial Ca(2+) uptake and efflux have been identified. The identification of the mitochondrial Ca(2+) uniporter (MCU) led to an explosion of studies identifying regulators of the MCU. The levels of these regulators vary in a tissue- and disease-specific manner, providing new insight into how mitochondrial Ca(2+) is regulated. This review focuses on the proteins responsible for mitochondrial transport and what we have learned from mouse studies with genetic alterations in these proteins.