Abstract
OBJECTIVE: To summarize the expression and role of CD146 in mesenchymal stem cells (MSCs). METHODS: The literature related to CD146 at home and abroad were extensively consulted, and the CD146 expression in MSCs and its function were summarized and analyzed. RESULTS: CD146 is a transmembrane protein that mediates the adhesion of cells to cells and extracellular matrix, and is expressed on the surface of various MSCs. More and more studies have shown that CD146 (+) MSCs have superior cell properties such as greater proliferation, differentiation, migration, and immune regulation abilities than CD146 (-) or unsorted MSCs, and the application of CD146 (+) MSCs in the treatment of specific diseases has also achieved better results. CD146 is also involved in mediating a variety of cellular signaling pathways, but whether it plays the same role in MSCs remains to be demonstrated by further experiments. CONCLUSION: The utilization of CD146 (+) MSCs for tissue regeneration will be conducive to improving the therapeutic effect of MSCs.