Abstract
Pulsed Field Ablation (PFA) is a novel ablation technology that utilizes electric field strength to ablate tissue. PFA is unique in its cell selectivity, which is found in the biophysics of the bilipid membrane's sensitivity to electric fields. PFA permits an unseen level of flexibility in its delivery due to its non-abrasive ablation methods and ability to selectively ablate regardless of direct contact. With the ability to electrically isolate each electrode, it is possible to dynamically map and ablate according to patient-specific "mechanistic" targets. Testing was done to determine the efficacy of the PFA system, the influence that electrode configuration has on PFA lesion size, and the acute lesion formation timeline. PFA lesion depth can be doubled (1mm to 2mm) through modulating electrode configuration and polarity. Significant electrophysiological changes were only recorded immediately post ablation. Electrode configurations appeared to generate the same level of tissue damage at PFA sites while significantly increasing depth without increasing voltage, which could introduce more risks and complications.