Abstract
BACKGROUND: The two previous versions of the Scandinavian donations and transfusions (SCANDAT) databases, encompassing data on blood donors, blood components, transfusions, and transfused patients linked to national health registers in Sweden and Denmark up until 2012, have been used to study donor health, disease transmission, the role of donor characteristics, and more. STUDY DESIGN AND METHODS: Here we describe the creation of the Swedish portion of the third iteration of SCANDAT - SCANDAT3-S - with follow-up from 1968 to the end of 2017, resulting in up to 50 years of uninterrupted follow-up for donors and recipients. The database now also includes non-transfused non-donors with a blood typing result, increased temporal resolution for transfusions, and linkages to laboratory and drug prescription data. RESULTS: After data cleaning, the database contained 23 579 863 donation records, 21 383 317 transfusion records, and 8 071 066 unique persons with valid identification. In total, the database offers 28 638 436 person-years of follow-up for donors, 13 582 350 person-years of follow-up for transfusion recipients, and 65 613 639 person-years of follow-up for non-recipient non-donors, with possibility for future extension. Additionally, the database includes 167 820 412 dispense records for prescribed drugs and 316,338,442 laboratory test results. Since the latest update in 2012, >99.9% of all donations were traceable to a donor with valid identification, and >97% of all transfusions to a recipient with valid identification. CONCLUSION: With extended follow-up and more clinical detail, the Swedish portion of the third and latest iteration of the SCANDAT database should allow for more comprehensive analysis of donation and transfusion-related research questions.