Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides

不对称单萜杂芳基二硫化物的合成及生物活性

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作者:Denis V Sudarikov, Yulia V Gyrdymova, Alexander V Borisov, Julia M Lukiyanova, Roman V Rumyantcev, Oksana G Shevchenko, Diana R Baidamshina, Nargiza D Zakarova, Airat R Kayumov, Ekaterina O Sinegubova, Alexandrina S Volobueva, Vladimir V Zarubaev, Svetlana A Rubtsova

Abstract

New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48-88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73-95% yields. The obtained compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity.

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