Abstract
Segmental arterial mediolysis (SAM) is a rare, noninflammatory disease process that leads to disruption of the arterial media. As the disease develops, it can lead to vascular aneurysm and dissection. This case follows a 39-year-old woman presenting with epigastric abdominal pain secondary to SAM and consequent pseudoaneurysm formation in the celiac artery. In this case, surgical intervention was a beneficial treatment when paired with antiplatelet therapy. Further documentation of SAM is necessary to broaden understanding of proper endovascular therapy and create adequate treatment protocols to improve patient outcomes.