Abstract
Skin-depigmenting creams are on the rise, driven by societal pressures that equate fair skin with beauty, success, and happiness. This trend has led to many unregulated products being released on the market, causing various adverse effects on users. This case report examines five patients with nail hyperpigmentation following the use of skin-depigmenting creams containing hydroquinone (HQ). The findings from this case report showcase overlooked side effects of these widely used creams. Healthcare providers may be unfamiliar with the rare side effects of depigmenting creams, leading to misdiagnoses and unnecessary evaluations. Moreover, there is a pressing need for healthcare authorities to enhance regulation and for healthcare providers to be more vigilant in diagnosing presentations of nail hyperpigmentation. This case report provides valuable insights into the side effects of HQ-based creams as observed in the Asiatic population.