Salt-losing syndrome as a mimicker of the Nephroprotective effect of Gliflozins in Proteinuric nephropathies

Gliflozins are oral antidiabetic drugs associated with a direct nephroprotective effect. Their administration reduces glomerular hyperfiltration and proteinuria by activating the tubule-glomerular feedback through an increased sodium delivery to the macula densa. We hypothesized a similar mechanism for nephroprotection in a patient with limited proteinuria, despite long-lasting glomerular damage secondary to suspected focal segmental glomerulosclerosis in a solitary kidney who also had salt-losing nephropathy.