Abstract
Epithelioid hemangioendothelioma (EHE) is a very rare vascular neoplasm in the anterior mediastinum. It is considered an intermediate-grade vascular neoplasm between benign hemangioma and highly aggressive angiosarcoma, with the potential for distant metastasis. The management of this disease is dependent on various factors such as the extent of tumor involvement, presence/absence of metastasis, and the general condition of the patient. Surgery is the treatment of choice with/without adjuvant chemo-radiotherapy in resectable disease. This case report presents the successful surgical management of a large invasive EHE in the anterior mediastinum in a 50-year-old woman.