Abstract
Personalized drug response prediction is an approach for tailoring effective therapeutic strategies for patients based on their tumors' genomic characterization. While machine learning methods are widely employed in the literature, they often struggle to capture drug-cell line relations across various cell lines. In addressing this challenge, our study introduces a novel listwise Learning-to-Rank (LTR) model named Inversion Transformer-based Neural Ranking (ITNR). ITNR utilizes genomic features and a transformer architecture to decipher functional relationships and construct models that can predict patient-specific drug responses. Our experiments were conducted on three major drug response data sets, showing that ITNR reliably and consistently outperforms state-of-the-art LTR models.