Abstract
BACKGROUND: Bonding agents play a critical role in the longevity and success of restorative dental treatments by minimizing microleakage at the tooth-restoration interface. The evolution from fifth- to eighth-generation bonding systems reflects the ongoing efforts to simplify procedures while improving clinical outcomes. MATERIALS AND METHODS: Sixty extracted human molars were divided into four groups based on the generation of bonding agents used: Fifth (Adper Single Bond 2), sixth (Clearfil SE), seventh (BeautiBond), and eighth (GC Premio Bond). Standardized Class V cavities were prepared and restored. Microleakage was assessed using methylene blue dye under a stereomicroscope. RESULTS: Eighth-generation bonding agent demonstrated the least microleakage, while the seventh generation showed the most. Statistical analysis confirmed significant differences among the groups (P < 0.05). CONCLUSION: The eighth-generation bonding agent showed superior performance in reducing microleakage compared to earlier generations, indicating its potential as the most effective adhesive system.