Abstract
This paper presents a case of a 43-year-old man with Down syndrome misdiagnosed with psoriasis, later diagnosed with CS. Clinical manifestations included pruritus, hyperkeratotic plaques, and yellow crusts on the scalp, hands, and feet. Laboratory findings revealed eosinophilia and confirmed scabies through mite identification. Treatment with oral ivermectin and permethrin cream led to complete lesion clearance in two weeks. Crusted scabies is highly contagious and often misdiagnosed, emphasizing the importance of early recognition and appropriate treatment to prevent complications and transmission.