Evaluation of the Safety of Cefazolin Monotherapy in Outpatient Parenteral Antimicrobial Therapy at a Large Academic Medical Center

In outpatient parenteral antimicrobial therapy, weekly lab monitoring is often standard practice, even for antimicrobials with low complication rates. We reviewed 420 patients treated with cefazolin: lab abnormalities associated with readmission or treatment changes occurred in 2% of patients. Reduced-frequency monitoring may be reasonable for patients treated with cefazolin outpatient.